Thymoma

This is a 46 year old male who is working as  a policeman. Through a routine medical checkup, X-ray chest showed  left anterior mediastinal rounded mass. (CXR-P-A)  - (CXR- Lateral)

CT scan chest showed homogeniously opaque single rounded mass closely related to the chest wall ( CT image). The mass has a clear line of cleavage from the surroundings. CT guided true cut biopsy was tried twice but it was conclusive.

The lesion was removed on  8/9/1998. Operative specimen: (image1) - (image2)

The histopathology report: THYMOMA   

One year later, he start to feel weakness while getting up and praying at night. He was referred to Neurologist who put him put on

    1- Mestinon     tab 60 mg t.d.s.

    2- Azathoprine tab 50 mg  b.d.

He improved a lot and was back to almost full duties

On 136/2004 He was readmitted to respiratory unit because of severe dry cough.

Chest x-ray showed left antero-medial and postero-lateral lesions.  CT chest confirmed the mass and showed that The postero-lateral lesion has a wide base towards the outside denoting an extra-pulmonary lesion. ( image1) - (image2

The antero-medial lesion is an irregular lobulated mediasitnal mass invading the aortic arch, descending aorta, left pulmonary trunk and left ventricle. (image1) - (image2)

 CT guided true-cut biopsy was taken and needle aspiration was performed.

Histopathology report: LYMPHOMA . patient was referred to oncologist for further management.

 

Literature :

Evidence that cell-mediated immunity is important:

The majority of patients with Burkett's lymphoma ( a tumor caused by Epstein-Barr virus) have inhibited cell mediated responses.

Among the few reports of thymoma and concomitant thymic T-cell lymphoma, only Macon et al. described a

case similar to ours. Both presented a benign encapsulated epithelial thymoma intermingled with blast-like lymphocytes,

without the widely infiltrative growth typical of the T-lymphoblastic lymphoma. Nevertheless, the involvement

of mediastinal lymph nodes by T-lymphoblasts in Maconís case, and the subsequent development of T-lymphoblast

metastases in our case, prove the malignant nature of the lymphoid cells.

Reference:
DOI: 10.1016/S1569-9293(03)00136-1
Interact CardioVasc Thorac Surg 2003;2:537-540
Francesca Rovera, Paola Billo, Carlo Capella and Lorenzo Dominioni
Concurrent epithelial thymoma and T-cell lymphoblastic lymphoma

 

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